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Due to the systemic mucus accumulated at different organs, clinical compliance is associated with malnutrition and poor absorption of foods in patients [108]

The role of EGFR in suppressing oxidative stress markers in an animal model of Parkinsons disease has also been clarified by a recent study, using Lapatinib (LAP), an anti-cancer drug that acts by mediating oxidative stress, with proven neuroprotective effects in case of epilepsy 37 .They observed that LAP restored glutathione/glutathione peroxidase (GSH/GPx) through the suppression of p-EGFR/c-SRC/PKCII/PLC-/ACSL-4 and PTGS2 38

[DOI] [PubMed] [Google Scholar] Davis RJ

In the absence of critical cofactors synthesis of the master antioxidant glutathione from Hcy cannot proceed