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The STEP 1 clinical trial showed participants on 2.4 mg semaglutide lost an average of 14.9% of body weight over 68 weeks

Before using a method for biomarker analyses, a species-specific validation is needed since clear differences in metabolism and excretion of GCs exist 10,13,36

This led to reduced cardiomyocyte apoptosis (decreased Bax/Bcl-2 ratio), lower inflammatory cytokine release (TNF- and IL-1) and inhibition of ferroptosis, as evidenced by reduced MDA and Fe2+ levels, along with increased GSH levels (124)

Its antimelanogenic properties shift melanin production from darker eumelanin to lighter pheomelanin, but have only minimal effects