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Previous research suggests DSIP can influence biosynthetic processes in the brain, reduce stress protein factors, and potentially affect glutamate and GABA receptors in regions like the cortex, thalamus, and hippocampus

The percentage of patients achieving headache response 4 hours after treatment was significantly greater in patients receiving 2 mg doses of dihydroergotamine mesylate nasal spray compared to those receiving placebo in 3 of the 4 studies (see Tables 1 & 2 and Figures 1 & 2)

eLife 6 , e28723 (2017)

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