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Nolla, University of Barcelona, Spain The article belongs to the special issue Complementary and Integrative Medicine in Rheumatology: Evidence, Therapies, and Clinical Impact Antioxidant and anti-inflammatory compound whose biological properties have been linked to modulation of oxidative stress, cytokine signaling, and bone metabolism

Itaconate is a dicarboxylic acid that is produced from the TCA cycle intermediate, cis -aconitate, by the enzyme aconitate decarboxylase 1 which is encoded by the ACOD1 gene

Although some data suggest that probiotics, prebiotics, and synbiotics can alleviate intestinal diseases, including IBD, their mechanisms of action remain unclear

doi: 10.1016/s0891-5849(97)00022-1