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In mice, intravenous injection of fluorescently labeled pHLIP-Ku80 () targeted tumors and reduced Ku80 expression

These studies provide insight into the involvement of group II mGlu receptors in drug-induced neuroadaptations as well as a potential mechanism by which mGlu 2/3 could be targeted for therapeutic purposes

In an evaluation of protein oxidation detected using a fluorescent probe targeted to sulfenic acid (DCP-Rho1) applied to cells activated with the lipid growth signal lysophosphatidic acid (LPA), our group recently found evidence for enhanced protein oxidation around redoxosomes (ROS-generating, signaling endosomes) which were also enriched in internalized LPA receptors [134]

Differential diagnosis: Hyperplasia, hepatocellular, regenerativeevidence of prior or ongoing hepatocellular damage