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In a study conducted in Andalusian health districts, on 17,429 total medical records selected in areas with high and low environmental exposure to pesticides, collected between 1998 and 2005, it was observed that the risk of developing neurodegenerative diseases, including MS, was significantly higher in districts with greater pesticides use (Parrn et al., 2011)

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Further research reveals that rhein can alleviate endoplasmic reticulum stress induced by H/R, upregulate GPX4 and SLC7A11 to mitigate lipid peroxidation, reduce renal ferroptosis, and protect against AKI (185)