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A., DiStefano, M

All statistical analyses were performed using the R software program (version 3.6.1)

Acknowledgments First and foremost, I would like to express my gratitude to Zhuo Xu, my tutor, who has taken off precious time from his busy schedule to read my thesis carefully and offer me constant encouragement, valuable suggestions and enlightening instructions, which contributed to the completion of my thesis

Surgery for example, may be contraindicated due to the health of the patient or may be unacceptable to the patient
