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found that excess manganese ions downregulated the expression of sirtuin1 to induce apoptosis of nerve cells, suggesting that blocking manganese ions-mediated cell death might have a certain prospect in developing therapeutics of neurodegenerative diseases (Zhao et al., 2019)

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Our findings align with previous studies linking low glutamine levels to increased insulin resistance and impaired skeletal muscle metabolism, with evidence that supplementing glutamine can improve insulin sensitivity, inflammation, and thus help in maintaining glucose homeostasis