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PRODH is transcriptionally regulated by p53 and plays important roles in apoptosis, autophagy and cellular stress adaptation, particularly under nutrient deprivation or oxidative stress 61,62

The G-site is predominantly contained in the N-terminal domain and binds GSH and primes the thiol sulfur for nucleophilic attack on an electrophilic substrate [77-79]

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The pain can be severe and incapacitating