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Dual inhibition of GGCT and xCT enhances antitumor efficacy in vivo without systemic toxicity To evaluate the therapeutic efficacy of dual GGCT and xCT inhibition in glioblastoma, we orthotopically implanted U87MG cells into the cerebral cortex of immunodeficient mice and treated them with pro-GA, the xCT inhibitor imidazole ketone erastin (IKE), or their combination

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