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After treatment initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

2018 Feb;38(1):174-183
By comparison, orlistat (Xenical) produced approximately 3-4 kg more weight loss than placebo over 12 weeks in its pivotal trials, and GLP-1 agonists produce 8-15 kg more than placebo

Medications like metformin (for diabetes), colchicine (for gout), and proton pump inhibitors (for acid reflux) can affect B12 levels
