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Consequently, inhibition of the ErbB pathway using its inhibitor PD158780 normalized mGlu1 receptor signaling, restored dopamine neuron hyperactivity, and alleviated repetitive behaviors, including reduction in self-grooming duration and marble-burying events [57]

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Together with clinical experience from POD-delivered dihydroergotamine (INP104) in migraine, these features support POD as a reliable, non-invasive platform with particular promise for neurological and psychiatric therapies (Starling et al., 2023)