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A common functional polymorphism of GSTP1 involves an A-G substitution in exon 5 (SNPsingle nucleotide polymorphism), resulting in the conversion of isoleucine to valine at position 105 of the amino acid chain (Ile105Val), which signicantly reduces the enzymatic activity of the protein [ 11 ]
However, the mechanism involved in these effects is still poorly understood and requires further investigation
