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Description
Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)

This is vastly more dilute than topical formulations, but isolated cells in culture have direct peptide access without any barrier to penetration
Further testing

A peptide describes the molecular structure (a chain of amino acids)
