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The accumulation of autolysosomes in the brain from AD patients mirrors the condition of compromised lysosomal proteolysis obtained via genetic knockdown of specific cathepsins or use of pharmacological inhibition of lysosomes (364366)

Abstract Fibromyalgia (FM) is a complex and common syndrome characterized by chronic widespread pain, fatigue, sleep disturbances, and various functional symptoms without clear structural or pathological causes

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The accumulated glycation of proteins in the lens may induce protein conformational changes that stimulate further glycation and oxidation as well as trigger protein aggregation leading to a cataract (54)