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In summary, this review provides a comprehensive overview of mitochondria, from their basic structure and functions to their roles in various diseases and the emerging therapeutic strategies targeting them

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NAD + (nicotinamide adenine dinucleotide) and NADH (reduced form of NAD + ) are crucial redox cofactors in diverse fields of metabolism and the balance of NADH/NAD + ratio is essential for sustaining a wide range of biological activities due to their critical functions in controlling the cellular redox condition, energy metabolism, mitochondrial function, cellular homeostasis, and signaling pathways 21,22,23,24,25,26,27

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