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Description
The pilocarpine-status epilepticus model in rats resembles the pathophysiology and chronic spontaneous seizures of TLE, whereas the pentylenetetrazole kindling paradigm demonstrates chronic caused limbic seizures

Moreover, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated Na + /Cl influx further disturbs osmotic balance, contributing to cytotoxic edema, a process blocked by AMPA antagonists (e.g., perampanel) in rodent models [139, 140]

They work alongside them

This oxidative stress directly damages mitochondrial DNA and the delicate lipid membranes of the organelles
