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doi: 10.15171/apb.2016.026

The most compelling mechanism is its proven ability to induce angiogenesisthe formation of new blood vessels

These data were confirmed in 2022 by a meta-analysis in which metformin utilisation after HCC curative treatment increased 3-year [OR = 1.50, 95% CI: 1.221.83] and 5-year (OR 1.88, 95% CI: 1.472.41) overall survival and decreased 1-year (OR = 1.31, 95% CI: 1.081.59), 3-year (OR = 1.88, 95% CI: 1.482.37), and 5-year (OR = 1.83, 95% CI: 1.402.40) recurrence rates [172]