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Hence, the downstream pathways are targeted for drug development
Increasing evidence also indicates that changes in fuel utilization are associated with changes in mitochondrial membrane dynamics through fusion and fission events
Consumption of a high fat diet results in a surplus of NADH and FADH 2 that then increases the flux through the ETC with a resultant increase in ROS generation
The consistency of the preclinical data across multiple studies and laboratories supports the mechanistic hypothesis
