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Description
While these emerging approaches hold promise, its important to acknowledge that they also have their limitations

The reduction of lipid accumulation by upregulation of SIRT6 expression may be related to the distinct effects of pyruvate dehydrogenase kinase 4 (PDK4) and angiopoietin-like 4 (ANGPTL4) downstream of SIRT6

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We view biasing as expressed on the observable systems level (Luttrell et al
