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Thus, the impairment of these systems can lead to longer contact times of formulations, physiologic impairment and damage of the mucosa and the nasal epithelium

4

248 They are composed of one or more lipid bilayers and hollow aqueous compartment, which endow them with loading versatility for both hydrophobic and hydrophilic therapeutic agents

Therefore, it is important to be aware that the use of DMSO as a solvent for the substance of our interest (even in amounts generally considered acceptable) may provide an additional source of oxygen atoms, sulfur atoms, or monocarbon units for the various processes normally occurring in the cells [13]