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For example, Sb9 A329S variant contributes to the pathogenesis of autoinflammatory disease due to its impaired ability to inhibit caspase-1 and IL-1, indicating Sb9 might play an important role in autoimmune diseases (107), pancreatitis (108), non-alcoholic steatohepatitis (109), severe generalized vitiligo (84), villous atrophy in celiac disease (110), chronic obstructive pulmonary disease (111), infections (69), graft injuries (70, 112), cardiovascular diseases (113), and polycystic ovary syndrome (114)

At any rate, the long-term effects of hydrochlorothiazide treatment on essential metabolic parameters such as body weight, body composition and dynamic evaluations of glucose homeostasis and metabolomics have not yet been conducted

The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review

(PubMed) Sano M, Bell K, Cote L, et al