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All patients included in the study are currently healthy and showing no signs of recurrence following complete excision of the lesion and at least 18 months of follow-up

[DOI] [PubMed] [Google Scholar] 40.Sharpe M.C., Archard L.C., Banatvala J.E., Borysiewicz L.K., Clare A.W., David A., Edwards R.H., Hawton K.E., Lambert H.P., Lane R.J., et al

They demonstrated that mutant form of PLC that lost its PIP2 hydrolyzing properties still can activate Ras-MAPK kinase pathway suggesting that this activation is due to Ras binding and GEF domain rather than to PIP2 hydrolysis [5]