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HIF-1 inhibition can usually be achieved through modulation of one of the following steps: HIF-1 mRNA expression

Albiston AL, Diwakaria S, Fernando RN, Mountford SJ, Yeatman H, et al

35 LiX.HuangY.HeY.YeA

These studies indicate that both insulin/IGF-1 and STAT3 signaling have fundamental roles in the differentiation of immunosuppressive phenotype of Tregs although the pathways need to be clarified in more detail
