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[DOI] [PubMed] [Google Scholar] 179.Ehlhardt W.J., Woodland J.M., Worzalla J.F., Bewley J.R., Grindey G.B., Todd G.C., Toth J.E., Howbert J.J

IGF-1 directly stimulates osteoblast proliferation and collagen synthesis, and it plays a critical role in the coupling of bone formation and resorption during remodeling

Pathologic angiogenesis is implicated in the proliferation of tumor cells, as well as in immune and inflammatory disease processes [68, 69]

Similar benefits appear in muscle injury, ligament repair, and bone fracture models
