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Contemporaneously, studies of synthetic guanidine analogues discovered a compound referred to as flumamine and suggested that it might act in patients with malaria by lowering blood glucose, thereby reducing the ability of the malarial parasite to survive

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There is every reason to argue that the efficacy observed for compounds 1 and 2 in vivo incorporates a similar role for the host immune response as seen for other schistosomicidal agents

Immunogenicity: A notable proportion of patients (approximately 70 % or more) may develop low-titer antibodies to sermorelin with chronic use