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430 Findings from clinical trials examining the use of SAMe for depression have been mixed, and most studies of SAMe in the context of depression have suffered from low methodological quality, design flaws, or small sample size

Ann Neurol Off J Am Neurol Assoc Child Neurol Soc 14:255260 Liu F, Wan Q, Pristupa ZB et al (2000) Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors

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This is done with Bacteriostatic Water, which is sterile water containing 0.9% benzyl alcohol to prevent bacterial growth