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doi:10.1016/j.ab.2009.12.028
We next exposed human Nalm6 cells deficient in FANCB , another Fanconi Anaemia DNA crosslink repair gene, to FA in the presence of L-BSO
167,168 In an EMT, epithelial cells lose apicobasal polarity and adhesive contacts while gaining actin stress fibers, anteroposterior polarity, motility, and remodeled contacts with neighboring cells and the ECM
Compared to strong oxidants like the hydroxyl radical, 4-HNE and MDA are relatively stable and able react with macromolecules, such as proteins distal to the site of origin
