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At the postsynaptic membrane, acetylcholine is hydrolyzed to acetate and choline by acetylcholinesterase to terminate the relay of the neurotransmission

however, it is removed by the dialysis machine itself, necessitating post-dialysis administration

Mitochondrial biogenesis is mainly controlled by a network of transcription factors in the nucleus, including peroxisome proliferator-activated receptor (PPAR), peroxisome proliferator-activated receptor (PPAR), estrogen-related receptors (ERRs), cylic AMP (cAMP) response element-binding protein (CREB), forkhead box (FOXO), and peroxisome proliferator-activated receptor coactivator-1 (PGC-1) (7477)