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For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation

However, since one of the common causes of Bell's palsy originates from herpes zoster and related viruses, the use of antiviral agents like acyclovir and valacyclovir in such instances is a common clinical practice with questionable benefits as a study conducted on 1,987 patients between 1966 and 2008, found no significant difference in the use of antiviral agents to treat Bell's palsy when compared with those who did not receive the medications

Archived from the original on January 14, 2017

Excessive accumulation of NAPQI depletes hepatic GSH stores, leading to oxidative stress, mitochondrial dysfunction, and covalent modification of cellular macromolecules