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Current guidelines recommend anti-CD38 antibody-based triplet combinations for relapsed/refractory disease after one to three prior lines of therapy, incorporating previously unused agents for lenalidomide- or bortezomib-refractory disease

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Microbial peptides, including mycobacteria-derived muramyl dipeptide (MDP), FK565, and Streptomyces -derived bestatin have shown anticancer properties [28]
