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The purpose of elongating the N-terminal acyl group and removing the N-terminal amino group was to increase the probability that resultant molecules might be BBB permeable and access the brain parenchyma
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Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia

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This ultimately promotes abnormal cell proliferation, inflammation, angiogenesis, immune escape and tissue infiltration
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