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The study has found that SFRP4 is involved in ISO-induced cardiomyocyte mitochondrial damage, and using an SFRP4 inhibitor can alleviate mitochondrial dysfunction in the myocardium and HL-1 cells (195)

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[DOI] [PubMed] [Google Scholar] [17].Nyman JS, Even JL, Jo CH, Herbert EG, Murry MR, Cockrell GE, Wahl EC, Bunn RC, Lumpkin CK, Fowlkes JL, Thrailkill KM, Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone, Bone 48 (2011) 733740, 10.1016/j.bone.2010.12.016

Dose-response relationships usually are not apparent for the provocation of allergic reactions
