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Because L--glutamyl-p-nitroanilide is disadvantageous for practical use in clinical chemistry testing due to its slight solubility, L--glutamyl-3-carboxy-4-nitroanilide, an alternatively modified substrate, is instead generally favored for easier handling in clinical examinations [85]

doi: 10.1021/acs.nanolett.5b05030

Despite the emergence of resistance, there was little concern because of the continuous production of new drug derivatives to manage the issue

Left untreated, these comedones can lead to more inflamed acne bumps, but worry not: using a product like a BHA exfoliant has the potential to speed up the process and eliminate the clogs that eventually lead to acne