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Among them, 1672 CT substitution in SLC22A4 exon 9 that leads to the L503F mutation, prevalently in Caucasian population, heightens development risk of IBDs and sporadic colorectal cancer in early age ( 10 times more Na + ion extracellularly than intracellularly) across the plasma membrane endows a robust driving force for EGT influx into cells and its avid retention there without comparable efflux [15, 36, 37]

In contrast, anti-inflammatory cytokines such as IL-10 and TGF- are required for maintaining Treg identity and suppressive capacity

doi: 10.1016/j.cmet.2011.11.004 34