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doi: 10.1053/j.gastro.2013.02.043
For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135
Overall, zebrafish serve as a multifaceted model for understanding the complex interactions between chemical exposures, genetic predisposition, and behavioral outcomes in cancer research
doi: 10.1186/s12974-021-02071-9 85 HuangM.WanY.MaoL.HeQ
