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For example, OTA induced strong down-regulation of regucalcin, which interferes with intracellular calcium regulation, a finding associated with nephrotoxic and nephrocarcinogenic compounds such as cisplatin [74,75]
129 Higher NOX4 levels have also been found in astrocytes of the cerebral cortex from AD patients, leading to disruption of mitochondrial metabolism and oxidative stress

doi: 10.2741/A812

Sun exposure: Going out without sun protection will speed up melanin production and reverse the effects