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In detail, the anti-tumor immune system can be divided into two major parts: innate immunity and adaptive immunity, whereas the immune cells in the TME are stratified as immunosuppressive cells and immunostimulatory cells, and the balance between them determines the occurrence and development of cancer
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Two tyrosines (Tyr1250 and Tyr1251) in the C-terminus of IGF-1R are considered to be essential for integrating IGF-1R and adhesion signaling [63]
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