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Description
Dermatological effects: Less frequently, patients may experience mild skin reactions, such as a temporary rash or pruritus (itching)
This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]
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Dong, Z., Zhang, X., Zhang, Q., Tangthianchaichana, J., Guo, M., Du, S., et al
