Nutri-West
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Description
In addition to mitochondria, other cytosol sources of ROS involve cytochrome P450 (CYP) superfamily of heme-thiolate enzymes, that functions as monooxygenases
Almost the entire N-terminal domain is a common region, while the C-terminal domain is interspersed with many variable regions located mainly in the loops between the helices
Overall, these architectural changes resemble changes in substrate-bound and substrate-free states of the Ycf1 homolog MRP1 (Supplementary Fig
doi:10.1177/039463201202500123 138
