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Similar content being viewed by others Introduction Attention-deficit hyperactivity disorder (ADHD), characterized by hyperactivity and inattention, affects between 3 and 5% in children and adolescents worldwide [1, 2]

The mechanisms by which inflammation affects tight junction structure and function and transcellular mechanisms such as endocytosis are largely unknown, although reproducible correlations have been observed between the severity of experimental and clinical disease and on the one hand and transepithelial electrical resistance, transport of paracellular markers, and systemic LPS concentrations and on the other [42, 86]

Future work should prioritize delivery platforms that localize exposure to pelvic lesions, including intraperitoneal or intralesional depots and nanocarriers, alongside triggerable or receptor-guided prodrugs designed to activate within the biochemical milieu of lesions

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