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Hyperhomocysteinemia increases risk of metabolic syndrome and cardiovascular death in an elderly Chinese community population of a 7-year follow-up study

A 2019 study found that older adults supplementing high doses of vitamin B12 were at an increased risk of colon cancer

Several RNAi drugs, including aptamers like pegaptanib targeting protein targets, and micro interfering RNAs like givosiran and patisiran, as well as antisense oligonucleotides like golodirsen and inotersen that interfere directly with RNA targets, have received FDA approval for medical use (Yu et al., 2020)

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