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doi: 10.1517/13543784.9.12.2889 291 PattersonAVFerryDMEdmundsSJGuYSingletonRSPatelKet al

Mechanistically, protection was primarily mediated by macrophage polarization toward the M2 reparative phenotype, whereas T-cell and neutrophil infiltration were largely unaffected

FIGURE 6 6 Conclusion Zebrafish-model provides an integrated pipeline spanning initial in vivo screening, toxicity evaluation, and mechanistic investigation, thereby serving as a pivotal translational bridge in the discovery and development of phytochemical-based anti-inflammatory therapeutics

As senescent cells seemed to be primed for ferroptosis, we reasoned that protective mechanisms against ferroptosis must be upregulated in senescent cells