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Complete healing of intestinal mucosa is the most desired goal in UC treatment (Supplementary Table S1, natural compounds can improve the barrier function of the UC mucosa through multiple perspectives, these include upregulation of the expression of tight junction protein, reduction in the intestinal mucosal, permeability, regulation of the intestinal mucus function, reduction of oxidative stress, and protection of the intestinal epithelial cells (Figure 4)

Altogether, epidemiological findings underscore that distal peripheral neuropathy is not exclusively associated with overt diabetes, but is also observed at a meaningful prevalence in individuals with prediabetes, suggesting an earlier onset of nerve involvement in the glycemic continuum

42,326,641643 For example, in-depth in silico analysis of the evolution of NRPS diversity by Baunach et al

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