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Ganessignh R (2021)

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Ratios of classical monocytes (CD14-/CD16-), which are more responsible for phagocytosis and initiation/priming of the immune system [254], are higher in patients with ALS and pre-symptomatic SOD1 carriers as compared with healthy controls, but function at a decreased efficacy and invade the CNS, though the difference between the roles of monocytes in the CNS versus systemic circulation are still unknown [255]

The 2011 study that I believe blazed the trail for the present-day hype over l-carnitine followed a 24-week daily dosing protocol