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In a phase 2 clinical trial among Chinese patients, mazdutide reduced HbA1c by 1.41% to 1.67% in a dose dependent manner compared to +0.03% for placebo
However, the performance of TfR-targeting strategies may vary depending on aging, disease stage, and neurovascular alterations, which may influence BBB biology and alter receptor-mediated transport (Petralla et al., 2024b
