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Plasma LC levels were shown to be lower in obese rats fed a HFD for a year, and this was concomitant to lower expression of hepatic regulatory LC genes

In preliminary intervention studies, pharmacologic doses of betaine (1,500 to 6,000 mg/day) were found to reduce blood homocysteine concentrations in a small number of volunteers with normal-to-mildly elevated homocysteine concentrations (37-40)

114 In another meta-analysis that pooled findings from eight randomized controlled trials, PNE was found to moderately reduce pain intensity but did not reduce fibromyalgia impact, catastrophizing, or anxiety

The gut microbiome in neurological disorders