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In cardiac surgery, direct contact between blood and the CPB circuit induces an inflammatory response mediated by cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) [3, 11]

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In some people, high intake of pyridoxine may contribute to peripheral neuropathy symptoms such as numbness, tingling, pain, and muscle weakness, mainly affecting the hands and feet

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