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If you take a 500 mg or 1,000 mg dose of Vitamin C at the same time as a B12 supplement, the Vitamin C can interfere with the "intrinsic factor." This is a protein made in your stomach that is absolutely necessary for B12 absorption later in the small intestine

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In contrast, oral supplements must pass through the digestive tract, where factors such as stomach acid, enzyme activity, and gut health can affect the absorption rate