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On the other hand, EGCG was shown to effectively attenuate the activity of dihydrofolate reductase (DHFR) and disrupt the folate cycle, thereby diminishing the cellular production of nucleotides by damaging the one-carbon pool (237, 238)
doi: 10.5230/jgc.2021.21.e40
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Firstly, the safety profiles of many supplements are not fully established, especially for long-term use
